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Sunday, July 19, 2020 | History

2 edition of Studies of mammalian brain development by fate mapping and mutant analysis. found in the catalog.

Studies of mammalian brain development by fate mapping and mutant analysis.

Dawn LenГ©e Zinyk

Studies of mammalian brain development by fate mapping and mutant analysis.

by Dawn LenГ©e Zinyk

  • 173 Want to read
  • 5 Currently reading

Published .
Written in English


The Physical Object
Pagination154 leaves.
Number of Pages154
ID Numbers
Open LibraryOL20505476M
ISBN 100612413578

  Cell migration is a key feature of mammalian brain development, with NP cells arising in a number of progenitor regions and subsequently migrating via distinct pathways to take up their final positions in the mature brain. Studies of neural cell migration have largely been performed in the mouse, taking advantage of the vast resource of genetically modified strains to investigate the roles of defined Cited by: 1. Alexiades, M.R. and Cepko, C., , Quantitative analysis of proliferation and cell cycle length during development of the rat retina, Dev. Dyn. – CrossRef PubMed Google ScholarCited by: 7.

The mammalian brain is an extremely complex structure both anatomically and functionally, that simultaneously integrates multiple inputs to produce an appropriate response (Sillitoe, ). Our studies are aimed at bringing together studies of neural development with analysis of the final circuitry and function of the adult brain. During the past two decades, the notion of a causal link between spindle/cleavage plane orientation and cell fate determination has been extended into studies of the mammalian brain and was thought to be a major mechanism governing the control of proliferation versus differentiation during mammalian neurogenesis (Homem et al. ).

Cortical histogenesis is the sequence of events by which the cerebral cortex develops into an organized laminar structure with distinctive cell types and synaptic connections, including excitatory.   These fate mapping studies, therefore, show that our new model is a combination of the two previously proposed models, differing on the basis Cited by:


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Studies of mammalian brain development by fate mapping and mutant analysis by Dawn LenГ©e Zinyk Download PDF EPUB FB2

Early brain organization is vividly demonstrated and local variations in brain development are shown in a holistic view. This book represents a key reference and interpretation matrix to analyze expression domains of genes involved in Zebrafish brain development and neurogenesis and thus represents a milestone in this research area.

Development. Twists of fate in the brain. These studies, prohibiting in vivo mammalian fate mapping, and has been limited by the inability Cited by: 3. Viral vectors are widely used to study the development, function and pathology of neural circuits in the mammalian brain.

Their flexible payloads with customizable choices of tool genes allow versatile applications ranging from lineage tracing, circuit mapping and functional interrogation, to translational and therapeutic : Wei Cong, Yun Shi, Yanqing Qi, Jinyun Wu, Ling Gong, Miao He. In vivo lineage tracing studies established that adult microglia derive from primitive myeloid progenitors that arise before embryonic day 8.

These results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain by:   While these fate-mapping studies are yet to be confirmed in human fetal brain, the results clearly indicate that neurodevelopmental disabilities presenting with malformations or dysplasia such as lissencephaly, microcephaly, autism, and epilepsy may also arise from abnormal specification or output from individual precursor by: Contrary to most genetic fate mapping studies, in clonal analysis, a low efficiency of recombination is an advantage since the labeling must be a rare event.

Therefore, lines with low expression levels of an inducible SSR can be by: This method was used to perform fate mapping of the nervous system in mammalian and chick embryos (Fekete and Cepko,Price et al., ) and to examine the properties of stem cells in adult mouse brain (Doetsch et al., ).Cited by: 3.

Taken together, the current results show great potential for MRI and DBM in studies of brain development and mutant phenotype analysis in mouse models of human neurodevelopmental disorders. MEMRI can be used for visualization and quantitative analysis of anatomy during the critical early postnatal period of brain development, and also enables Cited by: Fate-map analysis suggests that early differential molecular specification of progenitor regions and subregions in the neural plate and neural tube eventually correlates with specific prospective Author: Luis Puelles.

clustered around the third ventricle, the most distinct sexual dimorphic region in the mammalian brain; appears to have a role in reproductive behaviors. estrous cycle lesions to the preoptic area of the anterior hypothalamus in female rats causes a disruption in the ___.

Additional temporal control of recombination (e.g. genetic inducible fate mapping, GIFM) can be achieved by using an inducible Cre or Flp system, in which the Cre or Flp recombinase is fused with a mutant form of estrogen receptor (CreER or FlpER) that binds Tamoxifen, but not its endogenous ligands.

Upon Tamoxifen binding, Cre recombinase translocates from the cytoplasm to the nucleus and triggers recombination and reporter gene by:   The whole brain of Arx X*Y mutant mice (e) was smaller than that of the wild type (d), and the left and right olfactory bulbs of the mutant were positioned with a wide by: developmental ontology for the mammalian brain based on the prosomeric Evo-devo: an approach to the analysis of brain structure based on the merging of concepts drawn from evolution and embryonic development.: rhombomere, a result of several fate-mapping studies [27–.

Development - Twists of fate in the brain. has revolutionized fate mapping studies in mouse. Furthermore, using genetic fate mapping to mark cells has opened up the possibility of addressing.

These major questions in the field of mammalian taste development have remained unanswered due to lack of fate mapping studies that would label embryonic cell populations and remain indelibly.

Cells marked by genetic fate mapping can be studied in the context of mutant genes and other genetic alterations to reveal effects, for example, on their contributions to different tissues.

Another benefit of genetic fate mapping is that the embryonic cells under study are selected based on their expression of a particular gene or by the activity of a particular enhancer by: These results suggest that EP of Morpholino is a useful and powerful technique for analysis of gene functions during mammalian brain development.

Gain-of-function study in cultured mutant embryos Inoue et al. (a) have shown that ectopic cadherin-6 positive cells in the cortex side of wild-type mouse were sorted into the lateral ganglionic Cited by:   Using IUE to express fluorescent reporter molecules under the control of cell type or temporally specific DNA promoters is a powerful technique to map cell lineage and fate in the mammalian brain (Wang et al., ; Chen and LoTurco, ; Ohtaka-Maruyama et al., ).Cited by: Fate mapping of mammalian embryonic taste bud progenitors Article (PDF Available) in Development (9) June with Reads How we measure 'reads'.

Recent genetic loss of function studies and fate mapping analyses demonstrate that Ptf1a expression is required to generate the progenitors of cerebellar GABAergic neurons (Purkinje cells and interneurons) in the cerebellar ventricular zone (Hoshino et al.

Mammalian Brain Development examines the traditional "nature versus nurture" argument in the spectrum of brain development, discussing in particular sex differences in spatial perception ability, phenotype plasticity, disorders of brain development, Blood-Brain and placental barriers, chromosome abnormalities, as well as the use of imaging Author: Damir Janigro.Gene targeting has proven to be a powerful tool for precise manipulation of the mammalian genome, by generating thousands of mutant mouse strains.

Studies of these mutant mice have yielded extremely useful information in all fields of biological sciences, and theoretically, gene targeting can be used to generate mutant mice for all genes in the near by:   PDGFRα, specifically expressed by immature oligodendrocyte progenitor cells (OPCs) in the CNS, plays a critical role in OPC proliferation and migration.

However, it has been uncertain whether all cells of oligodendrocyte lineage are derived from the PDGFRα-expressing OPCs. In the present study, we uncovered a PDGFRα-independent oligodendrocyte lineage in the developing by: 3.